Robust immunity to influenza vaccination in haematopoietic stem cell transplant recipients following reconstitution of humoral and adaptive immunity

W Zhang; LC Rowntree; R Muttucumaru; T Damelang; M Aban; AC Hurt; M Auladell; R Esterbauer; B Wines; M Hogarth; SJ Turner; AK Wheatley; SJ Kent; S Patil; S Avery; O Morrissey; AW Chung; M Koutsakos; THO Nguyen; AC Cheng; TC Kotsimbos; K Kedzierska

Journal article

Robust immunity to influenza vaccination in haematopoietic stem cell transplant recipients following reconstitution of humoral and adaptive immunity

W Zhang, LC Rowntree, R Muttucumaru, T Damelang, M Aban, AC Hurt, M Auladell, R Esterbauer, B Wines, M Hogarth, SJ Turner, AK Wheatley, SJ Kent, S Patil, S Avery, O Morrissey, AW Chung, M Koutsakos, THO Nguyen, AC Cheng Show all

Clinical and Translational Immunology | WILEY | Published : 2023

DOI: 10.1002/cti2.1456

Abstract

Objectives: Influenza causes significant morbidity and mortality, especially in high-risk populations. Although current vaccination regimens are the best method to combat annual influenza disease, vaccine efficacy can be low in high-risk groups, such as haematopoietic stem cell transplant (HSCT) recipients. Methods: We comprehensively assessed humoral immunity, antibody landscapes, systems serology and influenza-specific B-cell responses, together with their phenotypes and isotypes, to the inactivated influenza vaccine (IIV) in HSCT recipients in comparison to healthy controls. Results: Inactivated influenza vaccine significantly increased haemagglutination inhibition (HAI) titres in HSCT re..

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University of Melbourne Researchers

WuJi Zhang Author

Louise Rowntree Author

Robyn Esterbauer Author

P. Mark Hogarth Author

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Grants

Awarded by University of Melbourne

Funding Acknowledgements

We thank Luca Hensen and Milla McLean for their technical assistance. This work was supported by the NHMRC Leadership Investigator Grant to KK (#1173871), NHMRC Emerging Leadership Level 1 Investigator Grant to THON (#1194036), AKW (#1173433) and MK (#1195698), Research Grants Council of the Hong Kong Special Administrative Region, China (#T11-712/19-N) to KK, the Victorian Government (SJK, AKW), MRFF Award (#2016062) to KK, THON, LCR, AKW, SJK and AWC, MRFF award (#2002073) to SJK and AKW, MRFF Award (#1202445) to KK, MRFF Award (#2005544) to KK, SJK and AKW, NHMRC programme grant 1149990 (SJK), NHMRC project grant 1162760 (AKW) and NIH contract CIVC-HRP (HHS-NIH-NIAID-BAA2018) to KK. SJK is supported by NHMRC Senior Principal Research Fellowship (#1136322). WZ is supported by the Melbourne Research Scholarship from The University of Melbourne. Open access publishing facilitated by The University of Melbourne, as part of the Wiley -The University of Melbourne agreement via the Council of Australian University Librarians.